Key Elements in Comparing Different Next-Generation Sequencing (NGS) Tests

Written by, Tariq M on January 1, 2025

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Next-generation sequencing (NGS) has revolutionised cancer care and is becoming ubiquitous across the cancer care continuum. Multiple studies have demonstrated the real-world, positive impact of NGS testing on improving patient outcomes through shortening time to results, facilitating tailored treatment strategies and better patient selection for clinical trials. The rapidly growing field has led to the commercialisation of NGS tests using a variety of gene panels that differ in size, gene content, mutation types that can be detected, and others. Hence, it is important to evaluate the factors that can impact the comprehensiveness, accuracy, quality and relevance of the test when comparing between different NGS tests.

  1. Panel content
 
  1. Genomic alterations detected
 
  1. Clinical relevance and interpretation
 
  1. Coverage and depth of sequencing
 
  1. Turnaround time and cost
 
  1. Validation and quality assurance
These factors can serve as a guide for oncologists to identify the most appropriate NGS test tailored to the specific clinical needs of their patients. Choosing the right NGS test enables more informed clinical decision-making, potentially leading to more personalized care and improved patient outcomes.
Figure: Factors that can impact the comprehensiveness, accuracy, quality and relevance of NGS tests

 

* Canary Oncoceutics has a steadfast commitment to three fundamental pillars: advancing scientific knowledge, fostering collaboration, and ultimately, enhancing the lives of cancer patients worldwide. From cutting-edge research to impactful clinical advancements, Canary Oncoceutics aims to illuminate the transformative potential of tailored cancer treatments. Join us on this journey towards a future where every cancer patient receives personalized, effective treatment tailored to their unique needs. *

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